El Rasheid Zakaria, MD, PhD, is a research assistant professor with the Department of Surgery, Division of Trauma, Clinical Care, Burn, and Emergency surgery.
Dr. Zakaria obtained his MD from Zagazig University, Egypt in 1983 and his PhD in nephrology, physiology, and biophysics from the University of Lund, Sweden in 1995. He joined the Department of Surgery in February of 2017, coming from the Translational Research Institute of Hamad Medical Corporation (HMC) in Doha, Qatar, where he worked for 7 years. As head of basic research at HMC, Dr. Zakaria established the first basic biomedical research using animal models of disease in the State of Qatar. He collaborated in the development and implementation of the HMC’s research strategic plan and served on research governance and research compliance committees.
Following his postdoctoral fellowship in nephrology, physiology, and biophysics with the University of Rochester in New York, Dr. Zakaria joined the University of Louisville in Kentucky as assistant professor in the Department of Physiology and Biophysics and the Surgical Research Service at the VA-Medical Center. At the University of Louisville, Dr. Zakaria participated in research, teaching, and the departments’ administrative services. He was the founder of the technique of Direct Peritoneal Resuscitation (DPR), which is currently translated for clinical use.
Dr. Zakaria was the recipient of many awards and recognitions, including service as research and development advisor to the NASA’s Exomedicine Consortium Project and a science advisor to the Exomedicine Institute. He has authored many publications in clinical and basic science journals and has a track record of research support, including funds from the National Institutes of Health (NIH), the American Heart Association (AHA), and the Qatar National Research Fund (QNRF).
- Control mechanisms of the microcirculation and their perturbation in traumatic hemorrhage, sepsis, septic shock, osmotic stress, and aging
- The pathophysiology of concurrent trauma and exsanguinations, including traumatic brain injury and the development of personalized therapies targeting critical pathways and adaptive pathophysiologic events at the molecular, cellular, and tissue levels
- The physiologic and biophysical mechanisms that govern solute and water exchanges across the blood-peritoneal barrier during peritoneal dialysis (PD) and the perturbations of these exchange functions by factors in the PD system that either individually or synergistically influence the functions of the blood-peritoneal barrier, inciting PD-technique failure or limiting PD-technique survival after long-term use. Host-related factors are: 1) aging; 2) kidney injury; 3) vascular and interstitial remodeling; and 4) uremia. System-related factors are: 1) peritoneal indwelling catheter as a foreign body; 2) bio-incompatibility of the clinical glucose-based PD solutions; 3) mechanical (intraperitoneal hydrostatic pressure)/osmotic load (hyper-osmolality) pressers; and 4) the immune response to PD and the PD-related peritonitis rate.
- The peritoneal cavity as a route for drug delivery in pelvic-abdominal cancers using a distributed approach in the anterior abdominal wall as a model of interstitial convection.