El Rasheid Zakaria, MD, PhD

Research Assistant Professor, Surgery

El Rasheid Zakaria, MD, PhD

Research Assistant Professor, Surgery

Dr. El Rasheid Zakaria obtained his MD from Zagazig University, Egypt in 1983; and his PhD in Nephrology, Physiology and Biophysics from the University of Lund, Sweden in 1995. He joined the Department of Surgery in February of 2017; from his most recent 7 years’ post as consultant with the Translational Research Institute of Hamad Medical Corporation (HMC), in Doha, Qatar. As head of basic research at HMC, Dr. Zakaria established the first basic biomedical research that uses animal models of disease in the State of Qatar. He collaborated in the development and implementation of the HMC’s research strategic plan, and served in research governance and research compliance committees. 

Following his postdoctoral fellowship in Nephrology, Physiology and Biophysics with the University of Rochester NY, Dr. Zakaria joined the University of Louisville KY, as assistant professor in the Department of Physiology and Biophysics; and the Surgical Research Service at the VA-Medical Centre. At the University of Louisville, Dr. Zakaria participated in research, teaching and in the Departments’ administrative services. Dr. Zakaria was the founder of the technique of Direct Peritoneal Resuscitation (DPR), which is currently translated for clinical use. Dr. Zakaria’s research interests include:

* The study of the control mechanisms of the microcirculation; and their perturbation in traumatic hemorrhage, sepsis and septic shock; osmotic stress, and ageing.
* The study of the pathophysiology of concurrent trauma and exsanguinations, including traumatic brain injury and the development of personalized therapies targeting critical pathways and adaptive pathophysiologic events at the molecular, cellular, and tissue levels.
* The study of the physiologic and biophysical mechanisms that govern solute and water exchanges across the blood-peritoneal barrier during peritoneal dialysis (PD); and the perturbations of these exchange functions by factors in the PD system that either individually or synergistically influencing the functions of the blood-peritoneal barrier, inciting PD-technique failure or limiting PD-technique survival after long-term use. Host-related factors are: 1) Aging; 2) Kidney injury; 3) Vascular and Interstitial remodeling; and 4) Uremia. System-related factors are: 1) Peritoneal indwelling catheter as a foreign body; 2) Bio-incompatibility of the clinical glucose-based PD solutions; 3) Mechanical (intraperitoneal hydrostatic pressure)/ osmotic load (hyper-osmolality) pressers; and 4) the immune response to PD and the PD-related peritonitis rate.
* The peritoneal cavity as a route for drug delivery in pelvic-abdominal cancers.  We apply the distributed approach in the anterior abdominal wall as a model of interstitial convection. This tumor-bearing model allows for the in vivo study of tumor biology and the simultaneous measurements of the tumor’s interstitial hydrostatic pressure and the chemotherapeutics’ concentration profiles across the whole thickness of the tumor.

 Dr. Zakaria was the recipient of many awards and recognitions including service as research and development advisor to the NASA’s Exomedicine Consortium Project; and a science advisor to the Exomedicine Institute. Dr. Zakaria has authored many publications in clinical and basic science journals. He has track records of research support, including funds from the National Institutes of Health (NIH), the American Heart Association (AHA) and the Qatar National Research Fund (QNRF).